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Application Notes - Molecular Spectroscopy

Exoscan FT-IR Instrument System Can Easily be Used in the Lab or Taken to the Field for Routine Analysis

February 1, 2009

Infrared spectroscopy has long been recognized as a selective and sensitive technique for analysis and characterization of surfaces. From material identification to quantitative analysis, infrared analyses can establish if a surface is composed of the correct material, has the proper coating thickness, is free of contaminants, is properly cured, or has the correct properties for the next step in a manufacturing process.

Impact of Containers on Raw Material Verification Using a Handheld Raman Spectrometer

February 1, 2009

Raman spectroscopy is a well-accepted, powerful tool for material identification, and the ability of a Raman spectrometer to acquire spectra through plastic and glass packaging materials protects sample integrity and greatly reduces analysis time.

Low-Concentration Melamine Detection with the IdentifyIR Diamond ATR Spectrometer

February 1, 2009

Detection of contaminants in consumer products is a critical public-safety need. One of the challenges of this type of detection is that the contaminant chosen is frequently designed to "fool" the routine product-safety testing performed. For example, melamine as the adulterant of choice to lower the cost of milk is because melamine contains nitrogen molecules.

The AGE Reader, a Novel Tool for Noninvasive Cardiovascular Risk Assessment

February 1, 2009

Cardiovascular diseases are among the most important causes of death in The Netherlands. It is of great importance to be able to detect these diseases at an early stage. However, current methods that use classical risk factors such as cholesterol and blood pressure do not come up to the mark.

Characterization of Amorphous and Microcrystalline Silicon Using Raman Spectroscopy

February 1, 2009

Abstract

Ruggedized NIR Spectrometers: Pharmaceuticals/Neutraceuticals/Food/Ag/PAT

February 1, 2009

Confirming the water content of pharmaceuticals and food during processing is critical for GmP results. The ability to measure water content until recently has been a difficult challenge until now. As a result of developments in the telecom industry, NIR spectrometers offer highly repeatable, cost effective solutions.

UV-Vis Diffuse Reflectance of Thermochromic Materials Including Color-Changing Paint

February 1, 2009

Some powders and rough surfaced solids change color as a function of temperature, a phenomenon known as thermochromism. Such phenomena can be effectively studied by UV-Visible spectroscopy in combination with a diffuse reflection accessory equipped with temperature-controlled reaction chamber, as demonstrated here with a thermal paint.

Structure and Thermodynamics of an mAb Biotherapeutic in Different Formulations

February 1, 2009

The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.

Analyzing Solar Cell Material Properties with Confocal Raman Microscopy

February 1, 2009

Energy generation using photovoltaic devices is regarded as an important component in overcoming future energy shortages. This is reflected in a dramatic increase in photovoltaic production and demand. In the research and development of photovoltaic devices, the primary goals are to increase the conversion efficiency of the solar cells or to improve the production process. The following study describes the application of Confocal Raman Imaging for the analysis of stress fields around laser-drilled holes on a Si solar cell using the large area scanning capabilities of the WITec alpha500 Confocal Raman Microscope.

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