 | Understanding and Interpreting the New GAMP 5 Software Categories
| | Spectroscopy - June 1, 2009 | | The GAMP (Good Automated Manufacturing Practice) guide version 5 was released in March 2008 and one of the changes was that the classification of software was revised — again. This column will look at what the changes mean for the laboratory and whether all of these should be implemented. |
|  | Statistics and Chemometrics for Clinical Data Reporting, Part I
| | Spectroscopy - June 1, 2009 | | This article describes the application of chemometric methods and statistics for reporting clinical quantitative measurement methods. The equations and terminology are consistent with the Clinical and Laboratory Standards Institute (CLSI) guidelines. These chemometric and statistical methods describe the accuracy and precision of a test method compared to a reference method for a single analyte determination. Part I will introduce these concepts and Part II will discuss the statistical underpinnings in greater detail. |
|  | Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]+2 with DNA and Determination of Nucleic Acids at Nanogram Levels
| | Spectroscopy - June 1, 2009 | | The interaction of [Ru(2, 2'-bipyridine)2(2-benzo[b] thien-2-yl-1H-imidazo[4,5-f][1,10] phenanthroline)]2+ ([Ru(bpy)2(BTIP)]2+) with nucleic acids in weak acidic medium is studied based upon the measurements of resonance light scattering (RLS) and UV–vis absorbance. Intercalation, electrostatic interaction, and long-range assembly are observed between [Ru(bpy)2(BTIP)]2+ and calf-thymus DNA (ctDNA). The enhanced RLS intensity is proportional to the concentration of ctDNA in an appropriate range. Three synthetic samples are analyzed satisfactorily. |
|  | Auger Spectroscopy
| | Spectroscopy - June 1, 2009
| | Some forms of spectroscopy involve actions other than measuring a property of light. In the case of this form of spectroscopy, the energies of emitted electrons are measured. |
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